Dwars door Vlaanderen will go ahead on Wednesday, despite the terrorist attacks that hit Brussels on Tuesday, but Giant-Alpecin will not be on the start line.
The German-registered team was left with just two riders who could make it to Belgium on time after all flights to the capital were cancelled.
Chad Haga, who was set to make his comeback from injuries suffered in a training crash in January, was held up in Spain with Caleb Fairly, while Frederik Ludvigsson was stuck in Sweden.
Due to the injuries suffered in a collision with a car in Calpe the team was already down to the minimum of six riders, rather than the allowed eight.
Movistar are reportedly badly hit as well; set to start the race with just four riders after Antonio Pedrero, Nelson Oliveira, Carlos Betancur and Jorge Arcas were removed from the line-up.