The Dutchman, who finished fourth overall at the Tour of Oman in February, leads an experienced Giant team, which is being stretched for resources with a number of riders out injured and two WorldTour stage races on the calendar next week.
New signing Laurens ten Dam will make his debut for the German team, having been brought in to help the likes of Dumoulin and Warren Barguil in the mountains.
Koen de Kort and Roy Curvers add more experience to the group, with Tour de France stage winner Simon Geschke a threat for a stage win in the ‘Race to the Sun’.
Coach Aike Visbeek said: “Our first focus will be to do a good prologue with Tom. From there on we will take it day by day to see what is possible in the general classification.
“With the experience of Koen and Roy we will be able to deal with the different conditions of the race. In addition, Laurens will bring that necessary experience for the mountains.”
Read our full preview of Paris-Nice here.