The Dutchman misjudged a corner and crashed hard into a bank of snow at the side of the road, flipping off his bike and landing on his back.
When he got up he realised his bike wasn't working and tried to fix it himself before a neutral service mechanic arrived.
The gearing was still broken when he got back on after a 30-second delay, leaving Kruijswijk spinning in a low gear.
Further down the mountain, Katusha leader Ilnur Zakarin was involved in a nasty crash, leaving him requiring medical attention off the side of the road.
On the climb of the Agnello, Orica-GreenEdge put the peloton to the sword, setting an incredibly high pace which left Kruijswijk without any teammates.
Michele Scarponi (Astana) scaled the mountain to claim the Cima Coppi.
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