The Dutchman misjudged a corner and crashed hard into a bank of snow at the side of the road, flipping off his bike and landing on his back.
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When he got up he realised his bike wasn’t working and tried to fix it himself before a neutral service mechanic arrived.
The gearing was still broken when he got back on after a 30-second delay, leaving Kruijswijk spinning in a low gear.
Further down the mountain, Katusha leader Ilnur Zakarin was involved in a nasty crash, leaving him requiring medical attention off the side of the road.
On the climb of the Agnello, Orica-GreenEdge put the peloton to the sword, setting an incredibly high pace which left Kruijswijk without any teammates.
Michele Scarponi (Astana) scaled the mountain to claim the Cima Coppi.