The Colombian hasn't managed to hit the heights he achieved in 2013 and 2014 in recent seasons, but will lead Cannondale into the year's first Grand Tour with a strong team around him.
Unlike in recent years with Etixx-Quick Step, Uran will have a team of domestiques dedicated to helping his title shot, with a lot of young climbing talent.
"Rigo is our leader in the Giro because he is a tough rider over three weeks," Vaughters said, quoted on Biciciclismo. "He is a tough, smart rider. Consistency is the key to making a great result, and that's what I see in Rigo at the moment.
"He has finished second twice in the Giro and has two stage wins. He may lack the power of [Vincenzo] Nibali, but he is a very smart rider."
Secrets of the Cannondale toolbox
Vaughters brought in Uran to lead his Giro squad in the offseason following the departure of Ryder Hesjedal to Trek-Segafredo.
Uran will be surrounded by the likes of Davide Formolo - stage winner in the 2015 Giro, Ramunas Navardauskas and Joe Dombrowski over the three weeks in Italy, a team that has the average age of just 26.
"We have made no secret that the Giro is our goal for the season," Vaughters continued. "It's a big goal for us, and the riders have proper preparation.
"This is the Giro, so you're never completely ready, although the team is ready. Rigo is going well and has a very good squad around him. He has a very good chance to win."
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