Sagan, who won the race overall in 2015 and has take 15 individual stage wins since 2010, will be the star attraction in California, with Elia Viviani (Team Sky), Alexander Kristoff (Katusha-Alpecin) and John Degenkolb (Trek-Segafredo) expected to provide his main competition in the sprints.
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Alongside Sagan in the Bora-Hansgrohe team will be his brother, and Slovakian national champion, Juraj Sagan, and Polish champion Rafal Majka, who has previously finished on the podium at the Vuelta a España.
The Bora-Hansgrohe line-up is completed by Jay McCarty, Pawel Poljanski, Michal Kolar, and Erik Baska.
The 2017 Tour of California starts on May 14 with a flat stage starting and finishing in Sacramento, and finishes six days later in Pasadena.