The Dutchman has reportedly been suffering from saddle sores in recent days and climbed off the bike at the feed zone and hopped into the team car.
Dumoulin wore pink for six days at the start of the Giro - winning the opening time trial in front of adoring fans in Apeldoorn, although he temporarily relinquished it to Marcel Kittel after stage three.
Tom Dumoulin's Giant Propel TT bike
He dropped 2-51 on the day and could only manage 15th place in the following day's time trial. Back in the saddle after the rest day, Dumoulin dropped a further 13 minutes on stage 10 to Sestola and looked disconsolate after the stage as his sores had not cleared up.
Dumoulin's next race will be the Tour of Poland, which starts on July 12, as he builds fitness and form for the Rio Olympic Games.
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