André Greipel and Caleb Ewan among those who will head to the airport after Friday's stage
Giro organiser RCS Sport offers no sprint finishes over the following eight stages towards Milan, where the race will end on Sunday, May 28.
“To be honest, this year, it’s not a hard question at all,” Greipel, who won stage two, told Cycling Weekly about the decision to leave.
“If you look at the parcours, you go home or you stay, but that decision is easy to make if you have the Tour de France in July.”
Greipel’s team has him scheduled to race the Tour de France for sprint stages so he will need to save energy to do so.
“It depends on the rider, some want to try for the ciclamino jersey and some are hunting for stages from escapes,” said sprinter Jakub Mareczko (Wilier-Selle Italia).
“The team often decides for you. After Tortona tomorrow, though, I need to think of my race programme coming up and what’s best, but the Giro’s three weeks helps you develop as a rider.”
Watch: Giro d’Italia stages 16-21 preview
Greipel, Ewan, Mareczko and others like Sam Bennett (Bora-Hansgrohe) could pull the plug. Others, like Colombian Fernando Gaviria (Quick-Step Floors), racing his first Grand Tour, will fight on to Milan.
“It’s the first Grand Tour in my career, my first three-week race,” Gaviria said. “It’s going well and the stage wins pushed me up to top in the points classification.
“I’ve never done anything this hard before, nothing compares to a three-week race. It’s clear that for my career, building up three weeks of racing and the kilometres in my legs is worth it. The Tour de France is not in my programme, so I can back off and think of the Vuelta a España.”
“It’s really important for me to be here in the Giro,” Greipel added. “I always want to challenge myself and compete against the best. That’s why I’m here, and I hope I can make the sprints a bit more interesting.
“If you don’t have the Tour de France in July, it’s really important to get through the Giro. You get three weeks, that’s something that makes you stronger as a rider.”