The Belgian pairing had been a lap down on Wiggins and Cavendish and Elia Viviani and Iljo Keisse after the second day of competition, but won four races on day three to retake the lead they had lost.
Wiggins/Cavendish enjoyed a successful start to the evening with Cavendish beating Otto Vergaerde in the final sprint of the team elimination, before De Ketele/De Pauw won the one lap time trial with a time of 8.58 seconds.
That meant that the Belgians went into the first madison on the evening ahead on points, but behind on laps, a situation that they remedied by finishing the race a lap ahead of the rest of the field.
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De Ketele/De Pauw continued to dominate through the rest of the evening, taking victory in one of the three derny races and setting a new ‘t Kuipke track record in the 500m time trial with a time of 26.650 seconds.
The final madison of the evening saw De Ketele/De Pauw finish without points, with the win being taken by Lindsay De Vylder and Leif Lampater, and Viviani/Keisse and Wiggins/Cavendish picking up 12 and 10 points respectively.
That result means that at the halfway mark De Ketele/De Pauw are in pole position with 230 points with Viviani/Keisse on 215 points and Wiggins/Cavendish on 204 points.
However with all three pairings on the same number of laps, the Ghent Six is still all to play for going into the crucial last three days.